GLOW INSTITUTE

Polynucleotide Microneedling: The New Generation of Skin Boosting

Discover the power of polynucleotides, an innovative skin booster that stimulates cell renewal, hydrates the skin, and refines skin texture.

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Polynucleotide treatment is currently one of the most talked-about skin-improving treatments, embraced internationally by celebrities, models, and skin experts who opt for natural skin rejuvenation. In international media and high-end clinics, this treatment is regularly linked to well-known names such as Kim Kardashian (known for the 'salmon DNA facial', based on polynucleotides) and various K-beauty celebrities, where polynucleotides have been part of advanced skin rejuvenation for years.

At Glow Institute, we combine polynucleotides with microneedling for maximum absorption and visible results. The skin becomes stronger, smoother, and healthier, with a fresh glow that continues to develop in the weeks following the treatment.

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Glow Institute

What is a polynucleotide microneedling treatment?

The polynucleotides in Croma PhilArt are sourced from the cells of freshwater fish, such as salmon. Polynucleotide microneedling stimulates cell renewal and promotes collagen production, resulting in tighter and more elastic skin.

Benefits of Polynucleotides for the skin

  • Intensive hydration: Improves moisture balance and provides a healthy glow
  • Skin rejuvenation: Reduces fine lines and wrinkles
  • Skin repair and soothing: Ideal for sensitive and stressed skin
  • Improvement of skin structure: Makes the skin firmer and smoother
  • Stimulation of collagen and elastin: For resilient, youthful skin

Who is this treatment suitable for?

The polynucleotide treatment is suitable for anyone who wants to improve their skin without adding volume. The treatment is particularly effective for:

  • Fine lines and early wrinkles
  • Tired or dull skin
  • Sagging skin
  • Dry or dehydrated skin
  • Dark circles and fine lines under the eyes
  • Damaged skin (sun, stress, aging)

This treatment is also safe and effective for sensitive skin or around the eyes.

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Polynucleotide Treatments and Costs

microneedling behandeling

Polynucleotide microneedling

Ideal as an intensive boost for overall skin improvement and rejuvenation. Polynucleotides are combined with microneedling to stimulate cell renewal, deeply hydrate the skin, and activate natural collagen production. The result is smoother, firmer, and fresher skin with a healthy glow.

€270

Ultimate Glow

The Ultimate Glow

The ultimate facial treatment for maximum skin improvement and visibly radiant skin. This complete treatment combines cleansing, connective tissue massage and extraction with BioRePeel, microneedling with polynucleotides and an exosome mask. Concluding with a relaxing shoulder-neck massage and collagen lamp. An all-in-one treatment for those who want to achieve the highest possible results for their skin.

€329

Glowing Skin Poly's Treatment

An intensive course of three treatments within eight weeks for long-lasting skin improvement. The combination of polynucleotides and microneedling improves skin structure, increases elasticity, and strengthens the skin barrier. Includes a free full-size iS Clinical HydraCool Serum (worth €83) and three free microneedling neck add-ons (worth €147) for complete and optimal results.

€810

Choose the microneedling treatment that suits you

For skin aging and fine lines

  • Polynucleotides: naturally improve skin quality and elasticity
  • Exosomes: strongly focused on cell communication and repair
  • Normal microneedling: stimulates collagen, but without active regenerative substances

For tired skin and dull complexion

  • Polynucleotides: deeply hydrate and improve skin structure
  • Exosomes: intensive recovery after skin stress
  • Normal microneedling: refines pores and structure
Donkere kringen

For skin around the eyes

  • Polynucleotides: very suitable, safe and effective for thin skin
  • Exosomes: possible, but less specific for this area
View all microneedling options
wallen behandeling voor en na

Treatment results

After a polynucleotide treatment, the skin looks fresher, more even, and firmer. Skin quality visibly improves in the weeks following the treatment.

  • Improved elasticity and firmness
  • Finer skin texture
  • More hydration and glow
  • Reduction of fine lines, including under the eyes

Optimal results are achieved after a course of several treatments.

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How does the treatment proceed?

The polynucleotide treatment follows a carefully structured step-by-step plan and typically lasts 45–60 minutes:

  1. Cleansing: The skin is first thoroughly cleansed to remove impurities and prepare the pores.
  2. Connective tissue massage: This step stimulates blood circulation and ensures that the skin is optimally prepared for microneedling.
  3. Microneedling with Polynucleotides: Fine needles are used to create micro-perforations in the skin, allowing the polynucleotides to penetrate deep into the skin. This stimulates the natural recovery process and accelerates skin regeneration.
  4. Mask: After microneedling, a nourishing mask is applied to further hydrate and soothe the skin.
  5. Collagen lamp: The treatment often concludes with a collagen lamp that promotes recovery and further stimulates collagen production.

Pre and post-treatment care

Before the treatment

  • Avoid sun, sauna, and active ingredients 5 days beforehand
  • Preferably come without makeup

After the treatment

  • Redness is normal and usually disappears within 24–48 hours
  • Use SPF and moisturizing products
  • Avoid intensive exercise and sun for 48 hours

Why choose Glow Institute?

Experienced and certified specialists

Our skin specialists are experts and stay up-to-date with the latest developments.

Personal skin analysis and treatment plan

Every treatment is tailored to meet your specific skin needs.

No standard treatments, but tailored to your skin

We use the latest technologies and scientifically-proven products that are demonstrably effective.

A treatment that improves your skin and enhances your well-being

Always a personalised treatment plan tailored to your needs.

High-quality equipment and treatment methods

We use the latest technologies and scientifically proven products that are demonstrably effective.

Focus on long-term results and minimal recovery time

For lasting results

Discover what polynucleotides can do for your skin

At Glow Institute, we combine expertise, high-quality products, and personalized attention for a polynucleotide treatment that strengthens your skin from within. Expect fresher, firmer skin and a natural glow, without significant downtime. Book your treatment now in Amsterdam, Rotterdam, or Oostvoorne and experience the benefits.

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Frequently asked questions

Is a polynucleotide treatment the same as a filler?

No. Polynucleotides do not add volume like fillers do. They improve skin quality by stimulating the natural repair process. The result is fresher, firmer skin without a "filled" effect.

Is the treatment safe for under the eyes?

Yes, polynucleotides are very suitable for the sensitive skin under the eyes. They help with fine lines, skin laxity, and a tired appearance, without weighing down the skin.

Does a polynucleotide microneedling treatment hurt?

The treatment is usually experienced as slightly tingling to mildly sensitive. If necessary, a numbing cream can be used to increase comfort.

How many treatments do I need to see results?

For optimal results, we usually recommend a course of 3 treatments, with several weeks in between. Skin improvement is often visible after the first treatment and continues to build up afterwards.

When will I see the final result?

The skin often looks fresher quickly, but the real results develop gradually in the weeks following the treatment, as collagen and elastin are produced.

Is there downtime after the treatment?

There is little to no downtime. The skin may be temporarily red and slightly sensitive, but this usually subsides within 24 to 48 hours.

Can I wear makeup after the treatment?

We recommend not using makeup for at least 24 hours, so that the skin can recover calmly and the active ingredients can work optimally.

Is the treatment suitable for every skin type?

Yes, polynucleotide treatment is suitable for almost all skin types, including sensitive skin. During the intake, we always assess whether the treatment is appropriate for your skin.

Can I combine polynucleotides with other treatments?

Absolutely. Polynucleotides are often combined with other skin-enhancing treatments, such as microneedling, exosomes, or peels, for an enhanced result, as in the Ultimate Glow treatment. We will tailor this in your personal treatment plan.

What is the difference between polynucleotides and exosomes?

Polynucleotides primarily focus on skin repair, hydration, and elasticity. Exosomes are more strongly focused on cell communication and recovery after intensive treatments. Which treatment is best suited depends on your skin condition and goals.